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Explore the side effects of Acetaminophen

As we know that Acetaminophen, is a fever reducer and pain reliever too. There are many benefits associated with the medicine, but you should also explore the side effects related to the medicine. Acetaminophen comes with side effects that can be mild to severe. When taken in excess amounts, the side effects of Acetaminophen can be fatal too. Let us explore the side effects of Acetaminophen so that you know how to use your medicine safely and get maximum benefits from your drug.

For some unwanted side effects you need immediate medical attention, so knowing about the side effects can help you understand your drug in detail.

Major Side effects

If you see some of the major and severe side effects while using Acetaminophen as listed below, contact your medical help immediately.

  • Tarry stools, black or bloody stools
  • Red spots on your skin
  • Hives, itching or skin rash
  • Fever with chills and fever without chills
  • Pain in side or in lower back (sharp or severe pain)
  • Sore throat
  • Sore ulcers
  • Unusual bruising or bleeding
  • Sudden decrease in urination
  • Unusual weakness or tiredness
  • Yellow skin or eyes
  • Cloudy or bloody urine

Over dose symptoms

These symptoms can occur as a result of overdose of Acetaminophen, cases ask for medical help immediately.

  • Increased sweating
  • Vomiting or nausea
  • Diarrhea
  • Appetite loss
  • Stomach pain or cramps
  • Pain, tenderness or swelling in upper stomach area or abdomen

Some common side effects of Acetaminophen are

  • Vomiting
  • Constipation
  • Nausea
  • Pain in injection site or reaction in injection site.


Increased – aspartate aminotransferase- common side effect

Increased – hepatic transaminases- rare side effect

Liver failure


Nausea and Vomiting

Constipation, enlarged abdomen, diarrhea, dyspepsia and constipation

Dry mouth


Hypersensitive reactions and Anaphylaxis


Postoperative hemorrhage – common side effect

Thrombocytopenia, neutropenia and leucopenia- Very rare effects


Pruritus and rash- common

Skin reactions (severe) – rare

Lyell syndrome, Pemphigoid reaction and Pustular rash- very rare


Dyspnea, hypoxia, coughing, pleural effusion, wheezing, stridor, breath sounds (abnormal), pulmonary edema

Some side effects do not need medical attention and they go away with time, but serious side effects needs medical attention. Do not consume alcohol while you are on Acetaminophen as it can lead to serious liver problems.

Speak to your doctor about the related side effects and how Acetaminophen is going to work for you. If you are using herbal supplements, vitamins or other products, you should let your doctor know as using Acetaminophen with these products can also lead to unwanted side effects. You doctor will be able to tell you about the contents present in supplements or other products you are taking and whether they can cause any serious effects when consumed with Acetaminophen.

Acetaminophen is a useful medicine if used as prescribed by the doctor. Do not ignore if you notice any unusual signs as they can be the side effects of Acetaminophen. You can treat these side effects, if you consult your doctor immediately.

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