Opioid analgesics may result in dependency. Operating a motor vehicle or machinery may be dangerous while using these pain medications because they can cause drowsiness. Opioids may slow down breathing. Mixing opioids with alcohol or certain other centrally-acting drugs could make this effect even worse.
Death and serious side effects have occurred with the use of fentanyl transdermal patches. Fentanyl patches are not recommended as starting therapy in inexperienced opiate users. Heat from the sun, hot baths, or heating pads can increase the speed of fentanyl release from patches.
Fentanyl buccal tablets have just one indication: treatment of breakthrough pain in cancer patients who are using and who have grown tolerant to opiates. Inappropriate use of fentanyl buccal tablets has resulted in death.
Methadone can affect the heart. Patients slated for methadone therapy should first have an EKG to check for abnormalities.