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Cyclic antidepressants are sometimes physical dependence

Cyclic antidepressants aren’t considered addictive, but sometimes physical dependence, which is different from addiction, can occur. So stopping treatment abruptly or missing several doses can cause withdrawal-like symptoms. This is sometimes called discontinuation syndrome. Work with your doctor to gradually and safely decrease your dose.

Withdrawal-like signs and symptoms can include:

Nausea and vomiting
Sweating
Flu-like symptoms
Lethargy
Headache
Dizziness
Muscle cramping
Irregular or rapid heartbeat

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